TB-500 10mg
A synthetic peptide corresponding to the actin-binding region of thymosin beta-4, supplied lyophilized for in vitro research into actin regulation, cell migration, and tissue-repair models.
Compound information
What is the Peptide?
TB-500 is a synthetic peptide commonly described as a fragment or analog of thymosin beta-4 (Tβ4), associated with the LKKTETQ amino-acid sequence. It is studied in actin regulation, cell migration, tissue-repair biology, angiogenesis, cytoskeletal dynamics, and peptide signaling, with research focusing on its interactions with actin-related pathways and cellular processes involved in tissue remodeling.
Structure
Stability information
Product overview
An actin-binding thymosin beta-4 fragment supplied for laboratory evaluation at a ≥99% HPLC analytical standard.
Technical overview
Thymosin beta-4 is a 43-amino-acid protein and one of the most abundant actin-sequestering molecules in mammalian cells. TB-500 isolates its most active segment, the seven-residue LKKTETQ motif at positions 17 to 23, and adds an N-terminal acetyl group for stability. That fragment retains the parent's actin-binding behavior while being much smaller.
It is produced by solid-phase synthesis and preparative purification, then released against a lot-matched Certificate of Analysis carrying HPLC purity and LC-MS identity.
Research applications
TB-500 is used to study actin dynamics and the cell movement that follows. Common laboratory work includes G-actin sequestration and filament assembly assays, endothelial and keratinocyte migration studies, wound closure and tissue remodeling models, and angiogenesis research. It is frequently paired with BPC-157 in repair-model work that examines vascular growth and cell migration together.
Kylo Peptides supplies this compound as a reference material for scientific inquiry. All applications must be conducted by qualified professionals in controlled laboratory environments. It has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.
Frequently Researched Together
Frequently Asked Questions
It binds actin, which is the protein that forms the internal scaffolding of a cell, and the LKKTETQ sequence lets TB-500 attach to individual actin units, influencing how the scaffolding assembles and disassembles. That process is central to how cells change shape and migrate, which is why the motif sits at the heart of repair research.
TB-500 is the short active piece of a much larger protein. Full thymosin beta-4 runs 43 amino acids and carries several functional regions, while TB-500 reproduces only the actin-binding stretch. That makes it smaller, more stable, and easier to synthesize, though it does leave behind the parent protein's other domains.
Every lot reads ≥99% by HPLC, with identity established by mass spectrometry. Independent third-party testing signs off on each batch before release, and the certificate for a given lot is available by the number printed on its vial.
Frozen and dry is the standard: −20 °C for regular holding and −80 °C for longer storage, kept sealed and out of light. After reconstitution, the solution should be stored at 2 to 8 °C, used within a validated window, and not repeatedly subjected to freeze-thaw cycles.
They cover complementary parts of repair. TB-500 drives actin-based cell migration, moving cells toward damaged tissue, while BPC-157 supports blood-vessel formation and cytoprotection. Because the two mechanisms operate side by side in the repair process, researchers frequently examine them together, which is the rationale behind the Wolverine blend, which combines them.
No. Kylo supplies TB-500 as a characterized reagent for in vitro laboratory research only. It is not prepared or labeled for use in humans or animals, and it is provided strictly to qualified researchers for controlled experimental work.
Backed By A Lot-Matched COA
Every TB-500 order is tied to a certificate of analysis matched to the exact lot in your vial.
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