SS-31 (Elamipretide) 10mg
SS-31 (Elamipretide) is a synthetic, cell-permeable tetrapeptide with the sequence D-Arg-2′,6′-dimethyltyrosine-Lys-Phe-NH₂. Unlike receptor-targeting peptides, the peptide is designed to concentrate at the inner mitochondrial membrane, where it interacts with the phospholipid cardiolipin.
Compound information
What is the Peptide
A four-amino-acid peptide engineered to home in on mitochondria. Its alternating charged and aromatic residues let it cross membranes without help and gather at the inner mitochondrial membrane, where it binds cardiolipin, the lipid that keeps the cell's energy machinery organized.
Structure
Stability information
Product overview
A cardiolipin-targeting mitochondrial tetrapeptide supplied for laboratory evaluation at a ≥99% HPLC analytical standard.
Technical overview
SS-31 belongs to the Szeto-Schiller family of mitochondria-targeting peptides, built from an alternating pattern of cationic and aromatic residues, including a modified dimethyltyrosine. That structure allows it to cross membranes without an energy source and concentrate heavily at the inner mitochondrial membrane, where it binds cardiolipin and supports membrane organization.
It is produced by solid-phase synthesis and preparative purification, then released against a lot-matched Certificate of Analysis carrying HPLC purity and LC-MS identity.
Research applications
SS-31 is studied as a tool for probing mitochondrial membrane biology. Common laboratory work includes cardiolipin-binding and membrane-stability assays in isolated mitochondria, reactive-oxygen-species and ATP-synthesis measurements under bioenergetic stress, electron-transport-chain function studies, and cell models of ischemia, aging, and mitochondrial dysfunction.
Kylo Peptides supplies this compound as a reference material for scientific inquiry. All applications must be conducted by qualified professionals in controlled laboratory environments. It has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.
Frequently Researched Together
Frequently Asked Questions
Through its own structure, without needing a targeting tag. SS-31 alternates positively charged residues with aromatic ones, a pattern that lets it slip across membranes on its own and build up at the inner mitochondrial membrane, reaching concentrations there thousands of times higher than in the surrounding cell.
Cardiolipin is a phospholipid found almost exclusively in the inner mitochondrial membrane, where it helps hold the energy-producing machinery in order. When mitochondria are stressed, cardiolipin becomes disorganized and energy production suffers. SS-31 binds cardiolipin directly, which is the basis of nearly all research interest in the peptide.
Each lot is confirmed at ≥99% by HPLC, with mass spectrometry verifying identity. Independent third-party testing clears every batch before release, and the certificate for a specific lot can be retrieved using the number printed on the vial.
Cold and dry is the rule. Hold the lyophilized powder at −20 °C, sealed and protected from light, dropping to −80 °C for long storage. After reconstitution, keep the solution at 2 to 8 °C, use it within a validated window, and avoid repeated freeze-thaw cycles.
It came out of the laboratories of Hazel Szeto and Peter Schiller, whose initials give the SS series its name. They designed a class of small peptides that could reach the inner mitochondrial membrane selectively, and SS-31, later named elamipretide, became the most studied member of that family.
No. Kylo supplies SS-31 as a characterized reagent for in vitro laboratory research only. It is not formulated or labeled for use in humans or animals, and it is provided strictly to qualified researchers for controlled experimental work.
Backed By A Lot-Matched COA
Every SS-31 order is tied to a certificate of analysis matched to the exact lot in your vial.
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