Sermorelin 10mg & 5mg
Sermorelin is a synthetic 29-amino-acid peptide corresponding to the biologically active N-terminal fragment of human growth hormone-releasing hormone (GHRH), also known as GHRH(1-29)-NH₂ or GRF(1-29)-NH₂. It acts on the growth hormone-releasing hormone receptor (GHRHR) and is studied for its effects on pituitary somatotroph signaling, endogenous growth hormone secretion, IGF-1 regulation, and the somatotropic axis.
Compound information
What is the Peptide?
The smallest piece of growth-hormone-releasing hormone that still works. Sermorelin reproduces the first 29 amino acids of GHRH, the segment that holds its full receptor activity, and binds the pituitary GHRH receptor to prompt growth-hormone release through cAMP signaling.
Structure
Stability information
Product overview
A minimal fully active GHRH fragment supplied for laboratory evaluation at a ≥99% HPLC analytical standard.
Technical overview
Sermorelin corresponds to residues 1 through 29 of human growth-hormone-releasing hormone, the shortest fragment that keeps full binding at the GHRH receptor. Its chain ends in a C-terminal amide, which is why it is often written GHRH(1-29)NH2. Acting on pituitary somatotroph cells, it triggers cAMP signaling and pulsatile growth-hormone release while leaving natural feedback control intact.
It is produced by solid-phase synthesis and preparative purification, then released against a lot-matched Certificate of Analysis carrying HPLC purity and LC-MS identity.
Research applications
Sermorelin is used as a compact, selective probe for GHRH receptor pharmacology. Common laboratory work includes GHRHR binding and cAMP-production assays, growth-hormone gene-transcription studies, receptor desensitization and competitive-displacement research, and somatotropic-axis models comparing fragment activity against full-length GHRH. It has also appeared in neuroendocrine tumor-cell proliferation studies.
Kylo Peptides supplies this compound as a reference material for scientific inquiry. All applications must be conducted by qualified professionals in controlled laboratory environments. It has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.
Frequently Researched Together
Frequently Asked Questions
Full GHRH runs 44 amino acids, but not all of them are needed for the molecule to work. Sermorelin keeps only the first 29, and research has shown that this segment retains receptor binding comparable to the whole hormone. Anything shorter begins to lose that activity, which is what makes 1-29 the practical minimum.
Sermorelin's chain ends in an amide group rather than a free acid, the reason it is written GHRH(1-29)NH2. That terminal amide contributes to how the fragment binds and stays active at its receptor, and it is a detail worth checking on any certificate, since it distinguishes correctly made sermorelin from a plain-acid variant.
Every lot is verified at ≥99% by HPLC, with identity confirmed through mass spectrometry. An independent third-party laboratory clears each batch ahead of release, and the certificate tied to a given lot can be looked up by the number shown on the vial.
Frozen and dry throughout. Keep the lyophilized powder at −20 °C, sealed away from light, and move to −80 °C for extended storage. After reconstitution, hold the solution at 2 to 8 °C, use it within a validated window, and do not put it through repeated freeze-thaw cycles.
They refer to the same peptide in different salt forms. The parent compound carries CAS 86168-78-7, while the acetate salt is often listed under a separate number. The peptide itself is identical, but researchers should confirm which form a certificate describes, since the salt affects the exact mass recorded.
No. Sermorelin provided by Kylo is a characterized reagent for in vitro laboratory research only. It is not formulated or labeled for use in humans or animals, and it is provided strictly to qualified researchers for controlled experimental work.
Backed By A Lot-Matched COA
Every sermorelin order is tied to a certificate of analysis matched to the exact lot in your vial.
Shop catalog →
