MOTS-c 40mg & 10mg
MOTS-c is an endogenous mitochondrial-derived peptide consisting of 16 amino acids and encoded within mitochondrial DNA. It is studied for its role in metabolic signaling, AMPK activation, glucose metabolism, insulin signaling, mitochondrial function, and cellular energy regulation.
Compound information
What is the Peptide?
A short peptide with an unusual origin: it is coded by mitochondrial DNA rather than the cell nucleus. Discovered in 2015, it acts as a signal from the mitochondria to the rest of the cell, activating AMPK and earning it the description of an exercise mimetic.
Structure
Stability information
Product overview
A mitochondrial-encoded metabolic peptide supplied for laboratory evaluation at a ≥99% HPLC analytical standard.
Technical overview
MOTS-c is encoded within the mitochondrial 12S rRNA gene, making it one of a small group of peptides written by mitochondrial rather than nuclear DNA. Its 16-residue sequence activates AMPK, the enzyme that governs cellular energy balance, partly by acting on the folate cycle, and it can move into the nucleus under stress to influence gene expression.
It is produced by solid-phase synthesis and preparative purification, then released against a lot-matched Certificate of Analysis carrying HPLC purity and LC-MS identity.
Research applications
MOTS-c is studied as a metabolic and mitochondrial signaling tool. Common laboratory work includes AMPK phosphorylation assays in muscle and HEK293 cells, glucose-uptake and insulin-sensitivity models, exercise-physiology and metabolic-aging research, and studies of the peptide's movement to the nucleus and its effect on antioxidant and metabolic gene expression.
Kylo Peptides supplies this compound as a reference material for scientific inquiry. All applications must be conducted by qualified professionals in controlled laboratory environments. It has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.
Frequently Researched Together
Frequently Asked Questions
Its source. Almost every peptide the body makes is coded by DNA in the cell nucleus, but MOTS-c is written into mitochondrial DNA instead. That places it in a rare group called mitochondrial-derived peptides, and it lets MOTS-c act as a direct signal from the mitochondria to the wider cell.
Because it switches on the same energy pathway that exercise does. MOTS-c activates AMPK, the enzyme that governs how cells manage fuel, prompting glucose uptake and fat oxidation. Endogenous levels also rise sharply in muscle after exercise, which is part of why researchers describe it in those terms.
Testing confirms ≥99% by HPLC on every lot, with mass spectrometry establishing identity. Independent third-party analysis clears each batch before release, and the certificate for a given lot can be pulled up using the number marked on the vial.
Keep it cold and dry. The lyophilized powder holds at −20 °C sealed and out of light, with −80 °C better for long storage. After reconstitution, the solution belongs at 2 to 8 °C, should be used within a validated window, and should not be cycled repeatedly through freezing.
All three sit in mitochondrial and energy-metabolism research, but they act differently. MOTS-c is a signaling peptide that activates AMPK, NAD+ is a redox coenzyme that carries electrons, and SS-31 targets the inner mitochondrial membrane. Researchers often study them within the same broader area of cellular energy and aging.
No. Kylo supplies MOTS-c as a characterized reagent for in vitro laboratory research only. It is not formulated or labeled for use in humans or animals, and it is provided strictly to qualified researchers for controlled experimental work.
Backed By A Lot-Matched COA
Every MOTS-c order is tied to a certificate of analysis matched to the exact lot in your vial.
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