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Catalog / Melanocortin / Melanotan 2
Melanocortin Peptide

Melanotan 2 10mg

MT-II · Cyclic Alpha-MSH Analog

Melanotan 2 is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH) that acts primarily on melanocortin receptors (MC1R, MC3R, MC4R, and MC5R). It is studied in melanocortin receptor pharmacology, pigmentation biology, signal transduction, and peptide-receptor interactions, with research focusing on receptor activation, cAMP signaling, and melanocortin pathways.

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Compound information

Chemical & structural properties
What it is

What is the Peptide?

A ring-shaped, seven-residue analog of the hormone alpha-MSH. Its cyclic structure makes it more compact and far more resistant to enzyme breakdown than the natural hormone, and it activates several melanocortin receptors, which places it at the center of pigmentation-pathway research.

Cyclic heptapeptideMelanocortin agonistResearch grade
ClassMelanocortin receptor agonist
OriginCyclic alpha-MSH analog
FormLyophilized powder
UseResearch use only
Molecular profile

Structure

TypeCyclic heptapeptide (7 aa)
CAS Number121062-08-6
Molecular Weight1024.18 g/mol
SequenceAc-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
FormulaC50H69N15O9
PubChem Database · CID 92432
Storage requirements

Stability information

Store coldProtect from lightKeep dry
Lyophilized (powder)
−20 °C · stable
Reconstituted
2–8 °C · short-term
Overview

Product overview

A cyclic melanocortin-agonist research peptide supplied for laboratory evaluation at a ≥99% HPLC analytical standard.

Technical overview

Melanotan 2 is a cyclic heptapeptide analog of alpha-MSH, closed into a ring by an internal lactam bridge that gives it compactness and enzyme resistance. A norleucine substitution replaces the oxidation-prone methionine of the natural hormone, further improving stability. It binds several melanocortin receptor subtypes rather than just one.

It is produced by solid-phase synthesis and preparative purification, then released against a lot-matched Certificate of Analysis carrying HPLC purity and LC-MS identity.

Research applications

Melanotan 2 is studied as a stable, broad melanocortin agonist. Common laboratory work includes MC1R and MC4R binding and signaling assays, melanogenesis and pigment-cell studies, receptor structure-activity research comparing the cyclic analog against linear alpha-MSH, and behavioral and feeding models exploring central melanocortin pathways.

For Research Use Only · Not for human or veterinary use

Kylo Peptides supplies this compound as a reference material for scientific inquiry. All applications must be conducted by qualified professionals in controlled laboratory environments. It has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.

FAQ

Frequently Asked Questions

It makes the peptide sturdier. A lactam bridge closes the amino acid chain into a ring, which holds the molecule in a fixed, compact shape and shields it from the enzymes that quickly dismantle linear peptides. That ring is the main reason Melanotan-II is far more stable than the natural alpha-MSH it is based on.

It is a redesigned copy of that hormone. Alpha-MSH is the body's own melanocortin signal, and Melanotan 2 reproduces its active core in cyclic form with substitutions that boost potency and stability. Unlike some alpha-MSH fragments that keep only one function, Melanotan-II retains broad melanocortin-receptor activity.

It means Melanotan 2 engages more than one melanocortin receptor. Rather than targeting a single subtype, it binds several, including MC1R and MC4R, which is why researchers use it as a broad melanocortin agonist and why receptor-selectivity studies often include it as a reference point.

Testing confirms ≥99% by HPLC on every lot, with mass spectrometry establishing identity. Independent third-party analysis clears each batch before release, and the certificate for a given lot can be retrieved using the number marked on the vial.

Keep it cold and dry. The lyophilized powder holds at −20 °C sealed and out of light, with −80 °C better for long storage. After reconstitution, the solution belongs at 2 to 8 °C, should be used within a validated window, and should not be cycled repeatedly through freezing.

No. Kylo supplies Melanotan 2 as a characterized reagent for in vitro laboratory research only. It is not formulated or labeled for use in humans or animals, and it is provided strictly to qualified researchers for controlled experimental work.

Backed By A Lot-Matched COA

Every Melanotan-II order is tied to a certificate of analysis matched to the exact lot in your vial.

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