KPV 10mg & 5mg
KPV is a synthetic tripeptide derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH), consisting of lysine, proline, and valine. Also known as Lys-Pro-Val, it is studied for its interactions with inflammatory signaling, immune pathways, cytokine regulation, and cellular signaling.
Compound information
What is the Peptide?
Three amino acids — lysine, proline, and valine — taken from the tail of the hormone alpha-MSH. It carries that hormone's ability to calm inflammation while leaving its pigment-producing region behind, and enters cells through the PepT1 transporter rather than a surface receptor.
Structure
Stability information
Product overview
An alpha-MSH-derived anti-inflammatory tripeptide supplied for laboratory evaluation at a ≥99% HPLC analytical standard.
Technical overview
KPV represents positions 11-13 of alpha-MSH, the smallest fragment that retains the parent hormone's anti-inflammatory activity. Its notable feature is its route: rather than binding to a melanocortin receptor, it is carried into cells by the PepT1 transporter and then blocks NF-κB signaling from within.
It is produced by solid-phase synthesis and preparative purification, then released against a lot-matched Certificate of Analysis carrying HPLC purity and LC-MS identity.
Research applications
KPV is used across inflammation research in several tissue systems. Common laboratory work includes NF-κB signaling and cytokine-reduction assays in intestinal epithelial cells, colitis and gut-barrier models that exploit PepT1 uptake, keratinocyte and skin-inflammation studies, and antimicrobial assays drawn from the activity of its parent hormone.
Kylo Peptides supplies this compound as a reference material for scientific inquiry. All applications must be conducted by qualified professionals in controlled laboratory environments. It has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.
Frequently Researched Together
Frequently Asked Questions
Through a nutrient transporter called PepT1, not a surface receptor. PepT1 normally carries small peptide fragments from digested food into intestinal cells, and KPV, being a tripeptide, is small enough to ride along. Since inflamed tissue produces more PepT1, the peptide tends to concentrate where inflammation is highest.
It is the tail end of that hormone. Alpha-MSH handles both skin pigment and inflammation control, and those functions sit in different parts of the molecule. KPV is the three-residue piece that carries the anti-inflammatory activity alone, without the region that drives pigmentation.
Each lot is measured at ≥99% by HPLC, with identity confirmed by mass spectrometry. An independent third-party laboratory clears every batch before it is released, and the matching certificate is published against the lot number marked on the vial.
Keep it frozen and dry. The lyophilized powder is stored at −20 °C, sealed from light, with −80 °C preferred for long-term storage. Once reconstituted, refrigerate the solution at 2 to 8 °C, use it within a validated window, and avoid putting it through repeated freeze-thaw cycles.
Gut inflammation leads the field, since the PepT1 route delivers the peptide directly to inflamed intestinal tissue, and colitis models are the most developed. Skin and wound research follows, drawing on the same NF-κB mechanism in keratinocytes, with a smaller body of antimicrobial work inherited from alpha-MSH.
No. Kylo supplies KPV as a characterized reagent for in vitro laboratory research only. It is not formulated or labeled for humans or animals, and it is provided strictly to qualified researchers for controlled experimental work.
Backed By A Lot-Matched COA
Every KPV order is tied to a certificate of analysis matched to the exact lot in your vial.
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