Kisspeptin-10 10mg
Kisspeptin-10 is a naturally occurring decapeptide derived from the KISS1 gene and an active fragment of the kisspeptin peptide family. Also known as Kp-10, it activates the kisspeptin receptor (KISS1R/GPR54) and is studied for its role in GnRH signaling, reproductive hormone regulation, hypothalamic signaling, and neuroendocrine pathways.
Compound information
What is the Peptide?
Biologically active 10-amino-acid peptide fragment derived from the KISS1 gene, functioning as an endogenous ligand for the kisspeptin receptor (KISS1R/GPR54). KISS1R activation stimulates Gq/11-mediated phospholipase C (PLC) signaling, increasing intracellular calcium and activating PKC/MAPK pathways, which promotes gonadotropin-releasing hormone (GnRH) secretion and downstream LH and FSH signaling.
Structure
Stability information
Product overview
A KISS1-derived bioactive decapeptide supplied for laboratory research at a ≥99% HPLC analytical stand
Technical overview
Kisspeptin-10 (Kp-10) is a biologically active C-terminal fragment of the KISS1 gene product and a potent endogenous ligand of the kisspeptin receptor (KISS1R/GPR54). Its defining feature is its role in hypothalamic neuroendocrine signaling, where KISS1R activation stimulates Gq/11-mediated PLC signaling, intracellular calcium mobilization, PKC/MAPK pathways, and downstream GnRH release. It is produced by solid-phase peptide synthesis and preparative purification, then released against a lot-matched Certificate of Analysis documenting HPLC purity and LC-MS identity.
It is produced by solid-phase synthesis and preparative purification, then released against a lot-matched Certificate of Analysis carrying HPLC purity and LC-MS identity.
Research applications
Kisspeptin-10 is used across reproductive and neuroendocrine research. Common laboratory applications include KISS1R receptor activation studies, GnRH secretion and pulsatility research, hypothalamic-pituitary-gonadal axis investigations, LH and FSH signaling assays, reproductive hormone regulation, puberty-related neuroendocrinology, and gonadal function research.
Kylo Peptides supplies this compound as a reference material for scientific inquiry. All applications must be conducted by qualified professionals in controlled laboratory environments. It has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.
Frequently Researched Together
Frequently Asked Questions
Kisspeptin-10 (Kp-10) is the shortest naturally occurring kisspeptin isoform and contains the C-terminal sequence responsible for full KISS1R activity. Kisspeptin-54 (Kp-54) is the longer precursor-derived isoform, while both share the same biologically active C-terminal decapeptide sequence.
Experimental studies have demonstrated that the peptide can produce rapid and dose-dependent changes in LH secretion. In a human study, intravenous Kisspeptin-10 increased LH pulse frequency from 0.7 to 1.0 pulses per hour during lower-dose infusion, making it a useful research tool for investigating pulsatile gonadotropin secretion and GnRH activity.
Each lot is measured at ≥99% by HPLC, with identity confirmed by mass spectrometry. An independent third-party laboratory clears every batch before it is released, and the matching certificate is published against the lot number marked on the vial.
Keep it frozen and dry. The lyophilized powder is stored at −20 °C, sealed from light, with −80 °C preferred for long-term storage. Once reconstituted, refrigerate the solution at 2 to 8 °C, use it within a validated window, and avoid putting it through repeated freeze-thaw cycles.
Research indicates that prolonged or continuous Kisspeptin-10 exposure can produce KISS1R desensitization and tachyphylaxis. Experimental studies have linked this response to β-arrestin recruitment, receptor internalization, and altered receptor recycling. In contrast, intermittent kisspeptin exposure can maintain stimulatory signaling, making exposure pattern an important variable in kisspeptin pharmacology research.
No. Kylo supplies Kisspeptin-10 as a characterized reagent for in vitro laboratory research only. It is not formulated or labeled for humans or animals, and it is provided strictly to qualified researchers for controlled experimental work.
Backed By A Lot-Matched COA
Every Kisspeptin-10 order is tied to a certificate of analysis matched to the exact lot in your vial.
Shop catalog →
